Which of the following is not a side effect of SGLT2 inhibitors?

SGLT2 inhibitors, which are primarily used for managing type 2 diabetes, have a range of known side effects that are critical for healthcare providers to understand. The side effects of SGLT2 inhibitors include ketoacidosis, yeast infections, and urinary tract infections, all of which are commonly observed in patients receiving this therapy.

Ketoacidosis can occur because SGLT2 inhibitors promote glucosuria, which may lead to a relative insulin deficiency and subsequently increase ketone production. Yeast infections and urinary tract infections are also observed due to the increased glucose in the urine, which creates an environment conducive to infection.

In contrast, hypertension is not associated with the use of SGLT2 inhibitors. In fact, these medications can have a beneficial effect on blood pressure, often leading to a reduction in systolic and diastolic blood pressure due to osmotic diuresis and subsequent volume reduction. Therefore, hypertension does not align with the known side effects of SGLT2 inhibitors, making it the correct answer in identifying which option is not a side effect.