Which medication is contraindicated for patients using Dofetilide?

Dofetilide is a Class III antiarrhythmic medication primarily used to treat atrial fibrillation and atrial flutter. One of the key concerns when using Dofetilide is its potential for causing torsades de pointes, a life-threatening form of ventricular tachycardia. As such, the use of medications that can increase the risk of this arrhythmia or that are known to interact adversely with Dofetilide must be carefully managed.

Amiodarone is known to significantly increase plasma levels of Dofetilide, raising the risk of serious arrhythmias, including torsades de pointes. The combination of these two medications can lead to dangerous heart rhythm disturbances. Therefore, the use of Amiodarone is contraindicated when a patient is prescribed Dofetilide, hence it is the correct choice in this scenario.

In contrast, Atorvastatin, Metoprolol, and Digoxin do not have the same level of interaction with Dofetilide and are not contraindicated in patients who are receiving Dofetilide. While each of these medications has its own profile and potential side effects, they do not significantly increase the risk of adverse cardiac events when