What medication class is associated with poor absorption of iron?

Proton pump inhibitors (PPIs) are known to affect the absorption of various nutrients, including iron. These medications work by reducing stomach acid production, which can lead to decreased solubility of iron in the gastrointestinal tract. Iron is better absorbed in an acidic environment, so when stomach acidity is diminished, the absorption efficiency of non-heme iron (the type of iron found in plant-based foods and supplements) can be significantly impaired. This effect is particularly important for individuals who may already be at risk for iron deficiency, making awareness of the interactions between PPIs and iron absorption essential in managing heart failure patients, who often experience concurrent conditions that require careful medication management.

In contrast, the other medication classes listed do not have a significant direct effect on iron absorption mechanisms. Beta-blockers primarily influence cardiovascular function and do not interact with nutrient absorption. Calcium channel blockers primarily affect calcium uptake and cardiac function, while thiazide diuretics are mostly associated with effects on sodium and fluid management rather than nutrient absorption.