What is the recommended daily dose of edoxaban for patients with a creatinine clearance less than 95?

The recommended daily dose of edoxaban for patients with a creatinine clearance less than 95 mL/min is indeed 30 mg. This dosage is especially crucial for patients with renal impairment because edoxaban is primarily eliminated via the kidneys. In patients with a creatinine clearance of 95 mL/min or higher, the standard dose is typically 60 mg. However, when creatinine clearance falls below this threshold, dose adjustment is necessary to mitigate the risk of accumulation and potential bleeding complications associated with the medication.

Edoxaban’s prescribing information emphasizes the importance of renal function assessment prior to initiating therapy, as improper dosing can have significant effects on patient safety. Therefore, the correct response reflecting the appropriate dose for renal impairment is vital for effective and safe anticoagulation management in heart failure and related conditions.