What is the initial bolus dose of Amiodarone for acute decompensated heart failure (ADHF)?

The correct initial bolus dose of Amiodarone for acute decompensated heart failure (ADHF) is typically 150 mg in 100 mL of D5W (dextrose 5% in water) administered over 10 minutes. This approach is standard due to the need for rapid control of potentially life-threatening arrhythmias that can occur in patients with heart failure.

Amiodarone is an antiarrhythmic medication that works both by altering the electrical activity of the heart and by stabilizing the myocardial membrane, making it crucial in managing various types of tachyarrhythmias that may accompany heart failure. The bolus administration allows for prompt therapeutic effects, which is essential in acute settings where the heart's function may be severely compromised, and immediate action is required.

In contrast, the other options provided are not suitable for an initial bolus in this acute context. Oral doses, such as 400 mg or 200 mg daily, do not provide the rapid intervention necessary for acute situations as they are meant for maintenance therapy or longer-term management. Additionally, a 300 mg dose given over 30 minutes is not the standard protocol for a bolus in an acute setting, as the focus is on