What is the initial bolus dose of amiodarone for ventricular tachycardia or fibrillation?

The initial bolus dose of amiodarone for the treatment of ventricular tachycardia or fibrillation, particularly in a cardiac arrest scenario, is 300 mg. This is the standard guideline followed in Advanced Cardiac Life Support (ACLS) protocols. Administering this dose is critical because it helps to quickly restore a normal rhythm during a life-threatening arrhythmia, enhancing the chances of successful defibrillation and improving the overall outcome for the patient.

Understanding that 150 mg is typically a loading dose used for other situations, such as in treating certain types of ventricular arrhythmias, clarifies why this dose is not correct for acute management during resuscitation. The higher doses presented in other options, such as 400 mg and 600 mg, significantly exceed the recommended bolus and could pose safety risks without contributing additional therapeutic benefit in this context. Therefore, recognizing the standard protocol for acute situations ensures effective and safe treatment for patients experiencing these critical conditions.