What is the benefit of using amlodipine in patients with HFpEF?

The benefit of using amlodipine in patients with heart failure with preserved ejection fraction (HFpEF) primarily revolves around its capacity for blood pressure control. Amlodipine is a calcium channel blocker that effectively lowers blood pressure by causing vasodilation, which can be particularly advantageous in heart failure patients who often present with hypertension. Controlling blood pressure is crucial in managing HFpEF, as elevated blood pressure can lead to increased workload on the heart and exacerbate symptoms of heart failure.

While some benefits related to functional improvement and symptom relief may be observed with amlodipine, these are secondary to the primary benefit of blood pressure management. Moreover, it is important to note that amlodipine does not enhance heart contractility or directly improve survival rates in heart failure patients, which further solidifies the rationale for its use in maintaining optimal blood pressure levels in individuals with HFpEF.