What is a common effect of loop diuretics that is also associated with thiazide diuretics?

The common effect of loop diuretics that is also associated with thiazide diuretics is an acute gout flare. Both types of diuretics can lead to elevated uric acid levels in the blood, which is a significant risk factor for gout. This occurs because diuretics can increase the reabsorption of uric acid in the renal tubules, thereby reducing its excretion. As uric acid accumulates, it can precipitate crystals in the joints, leading to the painful inflammation characteristic of a gout flare.

Understanding the mechanisms behind this effect helps highlight the importance of monitoring uric acid levels and considering a patient's history of gout when prescribing diuretics, especially in patients who are at increased risk for hyperuricemia. While other diuretics, such as loop and thiazide diuretics, can also have their own specific side effects and patient considerations, the relationship between these two drug classes and the potential for gout flares is a well-documented consequence of their use.