What is a common adverse effect associated with NSAIDs in the context of arthritis management?

In the context of arthritis management, fluid retention is a common adverse effect associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs). These medications can interfere with renal function by inhibiting the production of prostaglandins, which play a crucial role in maintaining renal blood flow and regulating sodium and water balance. As a result, NSAIDs can lead to increased sodium retention and fluid overload, which can worsen conditions in patients who are already at risk for heart failure or renal impairment.

Weight gain and weight loss are not directly tied to the typical adverse effects of NSAIDs in this context, as they often stem from different underlying causes or conditions. Hyperglycemia is more related to other classes of medications and metabolic conditions rather than being a direct effect of NSAIDs used for arthritis. Therefore, fluid retention stands out as the most relevant adverse effect in this clinical scenario.