What additional lab should be monitored while a patient is on digoxin?

Monitoring renal function is crucial for patients on digoxin due to the drug's pharmacokinetics and its potential toxicity. Digoxin is primarily excreted by the kidneys; therefore, any impairment in renal function can lead to an increased serum concentration of the medication, raising the risk of toxicity. Signs of digoxin toxicity can include nausea, vomiting, visual disturbances, and serious arrhythmias, which can be life-threatening.

When renal function is compromised, the clearance of digoxin decreases, making it essential to monitor serum creatinine and other markers of kidney function regularly. Adjustments to the digoxin dosage may be necessary based on the patient's renal status to avoid adverse effects. While electrolyte levels also play a role in digoxin therapy, particularly potassium and magnesium, the direct relationship between renal function and digoxin metabolism makes it a priority in the management of patients on this medication.